ERYTHROPOIESIS AND IRON KINETICS

Erythropoietin, iron, and erythropoiesis.

Recent knowledge gained regarding the relationship between erythropoietin, iron, and erythropoiesis in patients with blood loss anemia, with or without recombinant human erythropoietin therapy, has implications for patient management. Under conditions of significant blood loss, erythropoietin therapy, or both, iron-restricted erythropoiesis is evident, even in the presence of storage iron and i...

Erythropoiesis, erythropoietin, and iron.

Relationship Between Iron and Erythropoiesis

In recent years there has been important advancement in our knowledge of iron metabolism regulation that also has implications for understanding the physiopathology of some human disorders like beta-thalassemia and other iron overload diseases. In fact, progressive iron overload is the most salient and ultimately fatal complication of beta-thalassemia. Iron deposition occurs in visceral organs ...

Iron for erythropoiesis.

Rabbits were rendered anemic by cellular proliferation in response to phlebotomy, by parenteral administraanemia. The total amount of hemoglobin tion of phenyihydrazine and by phlesynthesized was determined by the supbotomy coupled with transfusion of nonply of iron to the marrow and was reviable erythroeytes. Measurements were flected in variations in hemoglobin conmade of the number and iron ...

Muscle iron in stress erythropoiesis?

17-92, an oncogenic polycistronic cluster that is targeted by both gene amplifications and deregulated c-MYC, resulting in its overexpression in the “centroblast-like” subgroup of DLBCL. Normally, miR-17-92 is expressed at higher levels in centroblasts compared with naive and memory B cells.4 c-MYC is not normally expressed in GCB cells, suggesting that the differential expression of miR-17-92 ...